Publications

Beyond the crystal structure of human macrophage C-type lectin

Gabba A, Murphy PV, Kiessling LL, Birrane G. Biochem. 2024 Jan 2 doi: 10.1021/acs.biochem.3c00642.

Glycan-costumed virus-like particles promote type I anti-tumor immunity

Lensch V, Gabba A*, Hincapie R*, Bhagchandani SH, Basak A, Alam MM, Irvine DJ, Shalek AK, Johnson JA, Finn MG, Kiessling LL. BioRxiv. 2024 Jan 18 doi: 10.1101/2024.01.18.575711.

Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis

Sturm A, Sun P, Avila-Pacheco J, Clatworthy AE, Bloom-Ackerman Z, Wuo MG, Gomez JE, Jin S, Clish CB, Kiessling LL, Hung DT. mBio. 2024 Jan 18 doi: 10.1128/mbio.03208-23

.

Rapid Single-Shot Synthesis of the 214  Amino Acid-Long N-Terminal Domain of Pyocin S2

Saebi A, Brown JS, Marando VM, Hatrampf N, Chumbler NM, Hanna S, Poskas M, Loas A,  Kiessling LL, Hung DT, Pentelute BL ACS Chem. Biol. 2023 Feb 23 doi: 10.1021/acschembio.2c00862.

Mycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection

Dulberger CL, Guerrero-Bustamante CA, Owen SV, Wilson S, Wuo MG, Garlena RA, Serpa LA, Russell DA, Zhu J, Braunecker BJ, Squyres GR, Baym M, Kiesling LL, Garner EC, Rubin EJ, Hartfull GF. Nat. Microbiol. 2023 Feb 23 doi: 10.1038/s41564-023-01333-x.

Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation

Al Mahbuba D, Masuko S, Wang S, Syangtan D, Kang JS, Song Y, Shin TW, Xia K, Zhang F, Linhardt RJ, Boyden ES, Kiesling LL. ACS Nano. 2023 April 12 doi: 10.1021/acsnano.2c10072 .

Identification of D-arabinan degrading enzymes in mycobacteria

Al-Jourani O, Benedict ST, Ross J, Layton AJ, Van Der Peet P, Marando VM, Bailey NP, Heunis T, Manion J, Mensitieri F, Franklin A, Abellon-Ruiz J, Oram SL, Parsons L, Cartmell A, Wright GSA, Baslé A, Trost M, Henrissat B, Munoz-Munoz J, Hirt RP, Kiessling LL, Lovering AL, Williams SJ, Lowe EC, Moynihan PJ.  Nat. Comm. 2023 April 19 doi: 10.1038/s41467-023-37839-5.

Lectin fingerprinting distinguishes antibody neutralization in SARS-CoV-2

Wuo MG, Dugan AE, Halim M, Hauser BM, Feldman J, Caradonna TM, Zhang S, Pepi LE, Atyeo C, Fischinger S, Alter G, Garcia-Beltran WF, Azadi P, Hung D, Schmidt AG, Kiessling LL.  ACS Cent. Sci. 2023 May 10 doi: 10.1021/acscentsci.2c01471.

Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions within oral commensals

Ghosh S, Ahearn CP, Isabella CR, Marando VM, Dodje GJ, Bartlett H, McPherson RL, Dugan AE, Jain S, Neznanova L, Tettelin H, Putnik R, Grimes CL, Ruhl S, Kiessling LL, Imperiali, B. PNAS 2023 May 22 doi: 10.1073/pnas.2216304120.

Lectin-Seq: a method to profile lectin-microbe interactions in native communities

McPherson RL*, Isabella CR*, Walker RL, Sergio D, Bae S, Gaca T, Raman S, Nguyen LTT, Wesener DA, Halim M, Wuo MG, Dugan AE, Kerby R, Ghosh S, Rey FE, Dhennezel C, Pishchany G, Lensch V, Vlamakis H, Alm EJ, Xavier RJ, Kiessling LL. Sci. Adv. 2023 July 28 doi: 10.1126/sciadv.add8766.

Assessing Squarates as Amine-Reactive Probes

Taylor KI*, Ho JS*, Trial HO, Carter AW, Kiessling LL. J. Am. Chem. Soc. 2023 November 8 doi: 10.1021/jacs.2c05691.

Selective Glycan Labeling of Mannose-Containing Glycolipids in Mycobacteria

Lee SY*, Marando VM*, Smelyansky SR, Kim DE, Calabretta PJ, Warner TC, Bryson BD, Kiessling LL. J. Am. Chem. Soc. 2023 December 19 doi: 10.1021/jacs.3c09495.

Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing

Chattopadhyay S, Teixeira LBC, Kiesling LL, McAnulty JF, Raines RT.
ACS Chem. Biol. 2022 January 27. doi: 10.1021/acschembio.1c00745. [PDF]

Biosynthetic incorporation for visualizing bacterial glycans.

Marando VM, Kim DE, Kiesling LL.
Methods Enzymol. 2022 January 28. doi: 10.1016/bs.mie.2021.12.005. [PDF]

Advances in glycoscience to understand viral infection and colonization

Dugan AE, Peiferr AL, Kiesling LL.
Nat. Methods. 2022 April 8. doi: 10.1038/s41592-022-01451-0.

Antibiotic action revealed by real-time imaging of the mycobacterial membrane

Wuo MG, Dulberger CL, Brown RA, Sturm A, Ultee E, Bloom-Ackermann Z, Choi C, Garner EC, Briegel A, Hung DT, Rubin EJ, Kiessling LL.
BioRxiv. 2022 April 11. doi: 10.1101/2022.01.07.475452 

Surface Presentation of Hyaluronic Acid Modulates Nanoparticle-Cell Association

Deiss-Yehiely E, Brucks SD, Boehnke N, Pickering, AJ, Kiessling LL, Hammond, PT. Bioconjugate Chem. 2022 October 25. doi: 10.1021/acs.bioconjchem.2c00412

Stereochemical Control Yields Mucin Mimetic Polymers

Kruger AG, Brucks SD, Yan T, Cárcarmo-Oyarce G, Wei Y, Wen DH, Carvahlo DR, Hore MAJ, Ribbeck K, Schrock RR, Kiessling LL.
ACS Cent Sci. 2021 March 30. doi: 10.1021/acscentsci.0c01569. [PDF]

Human intelectin-1 (ITLN1) genetic variation and intestinal expression

Nonnecke EB, Castillo PA, Dugan AE, Almalki F, Underwood MA, De La Motte CA, Yuan W, Lu W, Johansson MEV, Kiessling LL, Hollox EJ, Lönnerdal B, Bevins CL.
Sci Rep. 2021 June 18. doi: 10.1038/s41598-021-92198-9. [PDF]

Distinguishing Galactoside Isomers with Mass Spectrometry and Gas-Phase Infrared Spectroscopy 

Ho JS, Gharbi A, Schindler B, Yeni O, Brédy R, Legentil L, Ferrières V, Kiessling L. L., Compagnon I.
J. Am. Chem. Soc. 2021 July 8. doi: 10.1021/jacs.0c11919 [PDF]

Biosynthetic Glycan Labeling

Marando VM, Kim DE, Calabretta P, Kraft MB, BrysonBD, Kiessling LL.
J. Am. Chem. Soc. 2021 October 4. doi: 10.1021/jacs.1c07430 [PDF]

Synthetic Glycomacromolecules of Defined Valency, Absolute Configuration, and Topology Distinguish between Human Lectins

Hartweg M, Jiang Y, Yilmaz G, Jarvis CM, Nguyen HVT, Primo GA, Monaco A, Beyer VP, Chen KK, Mohapatra S, Axelrod S, Gómez-Bombarelli R, Kiessling LL, Becer CR, Johnson JA.
JACS Au. 2021 August 10. doi: 10.1021/jacsau.1c00255 [PDF]

Virtual screening for small-molecule pathway regulators by image-profile matching

Rohban MH, Fuller AM, Tan C, Goldstein JT, Syangtan D, Gutnick A, DeVine A, Nijsure MP, Rigby M, Sacher JR, Corsello SM, Peppler GB, Bogaczynska M, Boghossian A, Ciotti GE, Hands AT, Mekareeya A, Doan M, Gale JP, Derynck R, Turbyville T, Boerckel JD, Singh S, Kiessling LL, Schwarz TL, Varelas X, Wagner FF, Kafri R, Eisinger-Mathason TSK, Carpenter AE.
Cell Syst. 2021 September 2. doi: 10.1016/j.cels.2022.08.003 [PDF]

A proteome-wide atlas of lysine-reactive chemistry

Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VN, am Ende CW, Hacker SM, Ho J, Dix MM, Sucio R, Hayward MM, Kiessling LL, Cravatt BF
Nat. Chem. 2021 September 9. doi: 10.1038/s41557-021-00765-4 

CH−π Interactions in Glycan Recognition

Kiessling LL, Diehl RC.
ACS Chem. Biol. 2021 October 6. doi: 10.1021/acschembio.1c00413  [PDF]

Stereoelectronic Effects Impact Glycan Recognition.

McMahon CM, Isabella CR, Windsor IW, Kosma P, Raines RT, Kiessling LL.

J Am Chem Soc. 2020 Feb 5;142(5):2386-2395. doi: 10.1021/jacs.9b11699 [PDF]

Glycan-Modified Virus-like Particles Evoke T Helper Type 1-like Immune Responses.

Alam MM, Jarvis CM, Hincapie R, McKay CS, Schimer J, Sanhueza CA, Xu K, Diehl RC, Finn MG, Kiessling LL.
ACS Nano. 2020 Aug 17. doi: 10.1021/acsnano.0c03023. [PDF]

Polysaccharide length affects mycobacterial cell shape and antibiotic susceptibility

Justen AM, Hodges HL, Kim LM, Sadecki PW, Porfirio S, Ultee E, Black I, Chung GS, Briegel A, Azadi P, Kiessling LL.
Sci Adv. 2020 Sep 16. DOI: 10.1126/sciadv.aba4015. [PDF]

Modular Polymer Antigens To Optimize Immunity..

Bennett NR, Jarvis CM, Alam MM, Zwick DB, Olson JM, Nguyen HV, Johnson JA, Cook ME, Kiessling LL.
Biomacromolecules. 2019 Dec 9;20(12):4370-4379. doi: 10.1021/acs.biomac.9b01049. Epub 2019 Nov 11. [PDF]

Bacterial Cell Wall Modification with a Glycolipid Substrate.

PJ Calabretta, HL Hodges, MB Kraft, VM Marando, LL Kiessling.

J Am Chem Soc. 2019 Jun 12;141(23):9262-9272. DOI: 10.1021/jacs.9b02290. [PDF]

Angiomotin Regulates YAP Localization During Neural Differentiation of Human Pluripotent Stem Cells.

Y Zaltsman, S Masuko, JJ Bensen, LL Kiessling.

Stem Cell Reports 2019 s2213-6711(19)300094-3. doi:10.1016/j.stemcr.2019.03.009. [PDF]

Antigen Structure affects cellular routing through DC-SIGN.

CM Jarvis, DB Zwick, JC Grim, LR Prost, MM Alam, JC Gardiner, S Park, LL Zimdars, NM Sherer, LL Kiessling.

PNAS 2019 July 23, 160(30): 14862-14867 doi: https://doi.org/10.1073/pnas.1820165116 [PDF]

Chemoselective, Postpolymerization Modification of Bioactive Degradable Polymers.

JM Fishman, DB Zwick, AG Kruger, LL Kiessling.

Biomacromolecules 2019 Jan 4;20(2):1018-1027. [PDF]

Chemistry-Driven Glycoscience.

Kiessling LL.

Bioorganic & Medicinal Chemistry 2018 Oct 15;26(19):5229-5238. [PDF]

Polymers at the Interface with Biology.

Deming TJ, Klok HA, Armes SP, Becker ML, Champion JA, Chen EYX, Heilshorn SC, van Hest JCM, Irvine DJ, Johnson JA, Kiessling LL, Maynard HD, de la Cruz MO, Sullivan MO, Tirrell MV, Anseth KS, Lecommandoux S, Percec S, Zhong Z, Albertsson AC.

Biomacromolecules 2018 Aug 13;19(8):3151-3162. [PDF]

Imaging mycobacterial growth and division with a fluorogenic probe.

Hodges HL, Brown RA, Crooks JA, Weibel DB, Kiessling LL.
Proc Natl Acad Sci 2018 May 15;115(20):5271-5276. [PDF]

Deleterious Consequences of UDP-Galactopyranose Mutase Inhibition for Nematodes.

Winton VJ, Justen AM, Deng H, Kiessling LL.
ACS Chem Biol. 2017 Sep 15;12(9):2354-2361. [PDF]

Conformational Control of UDP-Galactopyranose Mutase Inhibition.

Wangkanont K, Winton VJ, Forest KT, Kiessling LL.
Biochemistry. 2017 Aug 1;56(30):3983-3992. [PDF]

Fidelity and Promiscuity of Mycobacterial Glycosylltransferase.

Yamatsugu K, Splain RA, Kiessling LL.
J Am Chem Soc. 2016 Jul 27; 138(29):9205-11. [PDF]

Recognition of Microbial Glycans by Soluble Human Lectins.

Wesener DA, Dugan A, Kiessling LL.
Curr Opin Struct Biol. 2017 Jun; 44:168-178. [PDF]

Comparing Galactan Biosynthesis in Mycobacterium tuberculosis and Corynebacterium diphtheriae.

Wesener DA, Levengood MR, Kiessling LL.
J Biol Chem. 2017 Feb 17; 292(7):2944-2955. [PDF]

Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP- Galactopyranose Mutase Probes.

Winton VJ, Aldrich C, Kiessling LL.
ACS Infect Dis. 2016 Aug 12;2(8):538-43. [PDF]

Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.

Wangkanont K, Wesenser DA, Vidani JA, Kiessling LL, Forest KT.
J Biol Chem. 2016 Mar 11;291(11):5596-610. [PDF]

Recognition of microbial glycans by human intelectin-1.

Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL.
Nat Struct Mol Biol. 2015 Aug;22(8):603-10. [PDF]

Multivalent Antigens for Promoting B and T Cell Activation.

Bennett NR, Zwick DB, Courtney AH, Kiessling LL.
ACS Chem Biol. 2015 Aug 21;10(8):1817-24. [PDF]

Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.

Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL.
ACS Chem Biol. 2015 Aug 17. [Epub ahead of print] [PDF]

The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain.

Wangkanont K, Forest KT, Kiessling LL.
Protein Expr Purif. 2015 Jun 11. pii: S1046-5928(15)00140-0. [PDF]

Forces of Change:Mechanics Underlying Formation of Functional 3D Organ Buds. Cell Stem Cell.

Wrighton PJ, Kiessling LL.
2015 May 7;16(5):453-4. [PDF]

Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.

Wrighton PJ, Klim JR, Hernandez BA, Koonce CH, Kamp TJ, Kiessling LL.
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18126-31. [PDF]

Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.

Guo LT, Wang YS, Nakamura A, Eiler D, Kavran JM, Wong M, Kiessling LL, Steitz TA, O’Donoghue P, Söll D.
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16724-9. [PDF]

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification.

Musah S, Wrighton PJ, Zaltsman Y, Zhong X, Zorn S, Parlato MB, Hsiao C, Palecek SP, Chang Q, Murphy WL, Kiessling LL.
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13805-10. [PDF]

Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells.

Sheridan RT, Hudon J, Hank JA, Sondel PM, Kiessling LL.
Chembiochem. 2014 Jul 7;15(10):1393-8. [PDF]

Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates.

Martinez Farias MA, Kincaid VA, Annamalai VR, Kiessling LL.
J Am Chem Soc. 2014 Jun 18;136(24):8492-5. [PDF]

New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.

Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ.
Biochemistry. 2014 Mar 18;53(10):1575-85. [PDF]

Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling.

Courtney AH, Bennett NR, Zwick DB, Hudon J, Kiessling LL.
ACS Chem Biol. 2014 Jan 17;9(1):202-10. [PDF]

A path to complex carbohydrates

Kiessling LL, Kraft MB.
Science. 2013 Jul 26;341(6144):357-8. [PDF]

UDP-Galactopyranose Mutase in Nematodes

Wesener DA, May JF, Huffman EM, Kiessling LL.
Biochemistry. 2013 Jun 25;52(25):4391-8. [PDF]

Glycopolymer probes of signal transduction

Kiessling LL, Grim JC.
Chem Soc Rev. 2013 May 21;42(10):4476-91. [PDF]

Synthesis of functionalizable and degradable polymers by ring-opening metathesis polymerization

Fishman JM, Kiessling LL.
Angew Chem Int Ed Engl. 2013 May 3;52(19):5061-4. [PDF]

Synthesis of lipid-linked arabinofuranose donors for glycosyltransferases

Kraft MB, Martinez Farias MA, Kiessling LL.
J Org Chem. 2013 Mar 1;78(5):2128-33. [PDF]

Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal

Musah S, Morin SA, Wrighton PJ, Zwick DB, Jin S, Kiessling LL.
ACS Nano. 2012 Nov 27;6(11):10168-77. [PDF]

Recasting Biomolecules for Function

Kiessling LL.
ACS Chem Biol. 2012 Jan 20;7(1):1-2. [PDF]

Non-Carbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists

Prost LR, Grim JS, Tonelli M, Kiessling LL.
ACS Chem Biol. 2012 Jul 19 [PDF]

Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase

Brown CD, Rusek MS, Kiessling LL.
J Am Chem Soc. 2012 Apr 18;134(15):6552-5. Epub 2012 Apr 10. [PDF]

Quinoxalinone Inhibitors of the Lectin DC-SIGN

Mangold SL, Prost LR, Kiessling LL.
Chem Sci. 2012 Mar;3(3):772-777. Epub 2011 Nov. 24. [PDF]

An Asymmetric Synthesis of l-Pyrrolysine

Wong ML, Guzei IA, Kiessling LL.
Org. Lett. 2012 Mar 16;14(6):1378-81. Epub 2012 Mar 6. [PDF]

A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site

May JF, Levengood MR, Splain RA, Brown CD, Kiessling LL.
Biochemistry. 2012 Feb 14;51(6):1148-59. Epub 2012 Feb 3. [PDF]

Small-Molecule-Modified Surfaces Engage Cells through the α(v)β(3) Integrin

Klim JR, Fowler AJ, Courtney AH, Wrighton PJ, Sheridan RT, Wong ML, Kiessling LL.
ACS Chem Biol. 2012 Mar 16;7(3):518-25. Epub 2012 Jan 26. [PDF]

Monitoring Processivity and Length Control of a Carbohydrate Polymerase.

Levengood MR, Splain RA, Kiessling LL.
J Am Chem Soc. 2011 Jul 25 Epub. [PDF]

Spatial control of cell fate using synthetic surfaces to potentiate TGF-B signaling.

Li L, Klim JR, Derda R, Courtney AH, Kiessling LL (2011)
Proc Natl Acad Sci USA. 108(29):11745-50. Epub 2011 Jun 30 [PDF]

Glycomimetic Building Blocks: A Divergent Synthesis of Epimers of Shikimic Acid.

Grim JC, Garber KC, Kiessling LL (2011)
Org. Lett. 2011 Jun 28 Epub [PDF]

Protein Footprinting in a Comples Milieu: Identifying the Interaction Surfaces of the Chemotaxis Adaptor Protein CheW.

Underbakke ES, Zhu Y, Kiessling LL (2011)
J Mol Biol.409(4):483-95 [PDF]

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells

Klim JR, Li L, Wrighton PJ, Piekarczyk MS, Kiessling LL (2010)
Nat Methods. 7(12):989-94 [PDF]

Classifying chemoreceptors: quantity versus quality.

Underbakke ES, Kiessling LL (2010)
EMBO J. 29(20):3435-6 [PDF]

Peptide ligands that use a novel site to target both TGF-beta receptors.

Li L, Orner BP, Huang T, Hinck AP, Kiessling LL (2010)
Mol Biosyst. 6(12):2392-402 [PDF]

A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.

Garber KC, Wangkanont K, Carlson EE, Kiessling LL (2010)
Chem Commun (Camb). 46(36):6747-9 [PDF]

Unexpected enhancement in biological activity of a GPCR ligand induced by a n oligoethylene glycol substitute.

Jiarpinitnum C, Kiessling LL (2010)
J Am Chem Soc. 132(26):8844-5 [PDF]

Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2.

Splain RA, Kiessling LL (2010)
Bioorg Med Chem. 18(11):3753-9 [PDF]

Chemical approaches to glycobiology.

Kiessling LL, Splain RA (2010)
Annu Rev Biochem 79:619-53 [PDF]

Decoding signals with chemical biology.

Kiessling LL. (2010)
ACS Chem Biol. 5(1):1-2 [PDF]

High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells.

Derda R, Musah S, Orner BP, Klim JR, Li L, Kiessling LL. (2010)
J Am Chem Soc. 132(4):1289-95 [PDF]

X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin

Gruber TD, Westler WM, Kiessling LL, Forest KT (2009)
Biochemistry. 48(39):9171-3 [PDF]

Flow cytometry reveals that multivalent chemoattractants effect swarmer cell dedifferentiation.

Lamanna AC, Kiessling LL (2009)
ACS Chem Biol. 4(10):828-33 [PDF]

A tethering mechanism for length control in a processive carbohydrate polymerization.

May JF, Kiessling LL (2009)
Proc Natl Acad Sci USA 106(29):11851-11856 [PDF]

Ligand binding and substrate discrimination by UDP-Galactopyranose mutase.

Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL. (2009)
J Mol Biol. 391(2):327-340 [PDF]

General synthetic route to cell-permeable block copolymers via ROMP.

Kolonko EM, Pontrello JK, Mangold SL, Kiessling LL. (2009)
J Am Chem Soc. 131(21):7327-7333 [PDF]

Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite.

Dykhuizen EC, Kiessling LL. (2009)
Org Lett. 11(1):193-196 [PDF]

Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation.

Courtney AH, Puffer EB, Pontrello JK, Yang ZQ Kiessling LL. (2009)
Proc Natl Acad Sci USA 106(8):2500-2505 [PDF]

Structure-based design of a periplasmic binding protein antagonist that prevents domain closure.

Borrok MJ, Zhu Y, Forest KT, Kiessling LL. (2009)
ACS Chem Biol. 4(6):447-456 [PDF]

ROMP from ROMP: A new approach to graft copolymer synthesis.

Allen MJ, Wangkanont K, Raines RT, Kiessling, LL. (2009)
Macromolecules. 42(12):4023-4027 [PDF]

Isotope-coded affinity tags with tunable reactivities for protein footprinting.

Underbakke ES, Zhu Y, Kiessling LL. (2008)
Angew Chem, Int Ed. 47(50):9677-9680 [PDF]

Synthesis of fluorogenic polymers for visualizing cellular internalization.

Mangold SL, Carpenter RT, Kiessling LL. (2008)
Org Lett. 10(14):2997-3000. PMID: 18563907 [PDF]

Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth.

Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. (2008)
J Am Chem Soc. 130(21):6706-7. PMID: 18447352 [PDF]

A polymeric domain that promotes cellular internalization.

Kolonko EM, Kiessling LL. (2008)
J Am Chem Soc. 130(17):5626-7. PMID: 18393495 [PDF]

Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array.

Borrok MJ, Kolonko EM, Kiessling LL. (2008)
ACS Chem Biol. 3(2):101-9. PMID: 18278851 [PDF]

Non-carbohydrate inhibitors of the lectin DC-SIGN.

Borrok MJ, Kiessling LL. (2007)
J Am Chem Soc. 129(42):12780-5. PMID: 17902657 [PDF]

Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers.

Derda R, Wherritt DJ, Kiessling LL. (2007)
Langmuir. 23(22):11164-7. PMID: 17880250 [PDF]

Site-directed mutagenesis of UDP-galactopyranose mutase reveals a critical role for the active-site, conserved arginine residues.

Chad JM, Sarathy KP, Gruber TD, Addala E, Kiessling LL, Sanders DA.(2007)
Biochemistry. 46(23):6723-32. PMID: 17511471 [PDF]

Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.

Borrok MJ, Kiessling LL, Forest KT. (2007)
Protein Sci. 16(6):1032-41. PMID: 17473016 [PDF]

Defined substrates for human embryonic stem cell growth identified from surface arrays.

Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. (2007)
ACS Chem Biol. 2(5):347-55. PMID: 17480050 [PDF]

A higher degree of difficulty.

Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. (2007)
ACS Chem Biol. 2(4):197-9. No abstract available. PMID: 17455890 [PDF]

Activating B cell signaling with defined multivalent ligands.

Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL. (2007)
ACS Chem Biol. 2(4):252-62. PMID: 17432821 [PDF]

Selective tumor cell targeting using low-affinity, multivalent interactions.

Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL. (2007)
ACS Chem Biol. 2(2):119-27. PMID: 17291050 [PDF]

Bifunctional Ligands that Target Cells Displaying the ?v?3 Integrin

Owen, R.M., Carlson, C.B., Xu, J., Mowery, P., Fasella, E., and Kiessling, L.L. (2007)
ChemBioChem, 8, 68 82. [PDF]

Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions

Carlson, C.B., Mowery, P., Owen, R.M., Dykhuizen, E,C,. and Kiessling, L.L (2007)
ACS Chemical Biology, Vol.2 No. 2, 119. [PDF]

Symbiosis: Chemical Biology at Wisconsin

Kiessling, L.L., Wedde, S.G., and Ronald T. Raines (2006)
ACS Chemical Biology, Vol.1 No. 8, 481. [PDF]

Synthetic Multivalent Ligands as Probes of Signal Transduction

Kiessling, L.L., Gestwicki, J.E. and Strong, L.E. (2006)
Angew. Chem. Int. Ed., 45, 2348 2368. [PDF]

Phage Display Affords Peptides that Modulate ?-Amyloid Aggregation

Orner B. P., Liu L., Murphy R.M., and Kiessling L.L. (2006)
J. Am. Chem. Soc., 128, 11882-11889. [PDF]

Chemical probes of UDP-galactopyranose mutase

Carlson, E. E., May, J. F., and Kiessling, L. L. (2006)
Chem Biol. 13, 825-837. [PDF]

Fostering major breakthroughs

Kiessling, L. L. (2006)
ACS Chem. Biol. 1, 1-2. [PDF]

 N-acylsulfonamide linker activation by Pd-catalyzed allylation

He, Y., Wilkins, J. P., and Kiessling, L. L. (2006)
Org. Lett. 8, 2483-2485. [PDF]

Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization

Allen, M. J., Raines, R. T., and Kiessling, L. L. (2006)
J. Am. Chem. Soc. 128, 6534-6535. [PDF]

Solid-Phase Synthesis of Polymers Using the Ring-Opening Metathesis Polymerization,

Pontrello, J.K., Allen, M.J., Underbakke, E,S, and Kiessling, L.L. (2005)
J. Am. Chem. Soc., 127, 14536-14537. [PDF]

Link between chemotactic response to Ni²⁺ and its adsorption onto the Escherichia coli cell surface, Environ.

Borrok, D., Borrok, M. J., Fein, J. B., and Kiessling, L. L. (2005)
Sci. Technol. 39, 5227-5233. [PDF]

Large increases in attractant concentration disrupt the polar localization of bacterial chemoreceptors

Lamanna, A. C., Ordal, G. W., and Kiessling, L. L. (2005)

Mol. Microbiol. 57, 774-785. [PDF]

Identification of Inhibitors for UDP-Galactopyranose Mutase

Soltero-Higgin, M., Carlson, E.E., Phillips, J.H. and Kiessling, L.L. (2005)
J. Am. Chem. Soc., 126, 10532-10533. [PDF]

Stereoselective N-Glycosylation by Staudinger Ligation

He, Y., Hinklin, R.J., Chang, J. and Kiessling, L.L. (2004)
Organic Letters, Vol. 6, No. 24, 4479-4482. [PDF]

Arrays for the Combinatorial Exploration of Cell Adhesion

Orner, B.P., Derda, R., Lewis, R.L., Thomson, J.A., and Kiessling, L.L. (2004)
J. Am. Chem. Soc., 126, 10808-10809. [PDF]

A unique catalytic mechanism for UDP-galactopyranose mutase

Soltero-Higgin, M. L., Carlson, E. E., Gruber, T. D., and Kiessling, L. L. (2004)
Nature Mol.Struct. Biol. 11, 539-543. [PDF]

Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding

Mowery, P., Yang, Z. Q., Gordon, E. J., Dwir, O., Spencer, A. G., Alon, R., and Kiessling, L. L. (2004)
Chem. Biol. 11, 725-732. [PDF]

Improved chemical synthesis of 1- and 5-Deazariboflavin

Carlson, E. E. and Kiessling, L. L. (2004)
J. Org. Chem. 69, 2614-2617. [PDF]

A polymer scaffold for protein oligomerization

Griffith, B. R., Allen, B. L., Rapraeger, A. C., and Kiessling, L. L. (2004)
J. Am. Chem. Soc. 126, 1608-1609. [PDF]

Surface plasmon resonance imaging studies of protein carbohydrate interactions

Smith, E. A., Thomas, W. D., Kiessling, L. L., and Corn, R. M. (2003)
J. Am. Chem. Soc. 125, 6140-6148. [PDF]

Parallel synthesis of glycomimetic libraries that target a C-type lectin

Schuster, M. C., Mann, D. A., Buchholtz, T. J., Johnson, K. M., and Kiessling, L. L. (2003)
Org. Lett. 5 , 1407-1410. [PDF]

Trophoblast L-selectin mediates adhesive interactions at the human maternal fetal interface

Genbacev, O. D., Prakobphol, A., Foulk, R. A., Krtolica, A. R., Ilic, D., Singer, M. S., Kiessling, L. L., Yang, Z. Q., Rosen, S. D., and Fisher, S. J. (2003)
Science 299, 405-408. [PDF]

Influencing receptor ligand binding mechanisms with multivalent ligand architecture

Gestwicki, J. E., Cairo, C. W., Strong, L. E., Oetjen, K. A., and Kiessling, L. L. (2002)
J. Am. Chem. Soc. 124, 14922-14933. [PDF]

Synthesis of a multivalent display of a CD22-binding trisaccharide

Yang, Z. Q., Puffer, E. B., Pontrello, J. K., and Kiessling, L. L. (2002)
Carbohydrate Res. 337, 1605-1613. [PDF]

A strategy for the synthesis of sulfated peptides

Young, T. and Kiessling, L. L. (2002)
Angew. Chem. Int. Ed. Eng. 41, 3449-3451. [PDF]

Conserved amplification of chemotactic responses through chemoreceptor interactions

Lamanna, A. C., Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Owen, R. M., and Kiessling, L. L. (2002)
J. Bacteriol. 184, 4981-4987. [PDF]

Affinity-based inhibition of ?-amyloid toxicity

Cairo, C. W., Strzelec, A., Murphy, R. M., and Kiessling, L. L. (2002)
Biochemistry 41, 8620-8629. [PDF]

Synthesis and applications of end-labeled neoglycopolymers

Owen, R. W., Gestwicki, J. E., Young, T., and Kiessling, L. L. (2002)
Org. Lett. 4, 2293-2296. [PDF]

Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy

Gestwicki, J. E., Cairo, C. W., Mann, D. A., Owen, R. M., and Kiessling, L. L. (2002)
Anal. Biochem. 305, 149-155. [PDF]

Cell aggregation by scaffolded receptor clusters

Gestwicki, J. E., Strong, L. E., Cairo, C. W., Boehm, F. J., and Kiessling, L. L. (2002)
Chem. Biol. 9, 163-169. [PDF]

Control of multivalent interactions by binding epitope density

Cairo, C. W., Gestwicki, J. E., Kanai, M., and Kiessling, L. L. (2002)
J. Am. Chem. Soc. 124, 1615-1619. [PDF]

Hitting the sweet spot

Kiessling, L. L. and Cairo, C. W. (2002)
Nature Biotech. 20, 234-235. [PDF]

Inter-receptor communication through arrays of bacterial chemoreceptors

Gestwicki, J. E. and Kiessling, L. L. (2002)
Nature 415, 81-84. [PDF]

Para-methoxybenzyl ether cleavage by polymer-supported sulfonamides

Hinklin, R. J. and Kiessling, L. L. (2002)
Org. Lett. 4, 1131-1133. [PDF]

Designed potent multivalent chemoattractants for Escherichia coli

Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Cairo, C. W., Schnoes, A. M., and Kiessling, L. L. (2001)
Bioorg. Med. Chem. 9, 2387-2393. [PDF]

Improved chemical synthesis of UDP-galactofuranose

Marlow, A. L. and Kiessling, L. L. (2001)
Org. Lett. 3, 2517-2519. [PDF]

Structure-function relationships for Inhibitors of b-amyloid toxicity containing the recognition sequence KLFVV

Lowe, T. L., Strzelec, A., Kiessling, L. L., and Murphy, R. M. (2001)
Biochemistry 40, 7882-7889. [PDF]

Glycosyl sulfonylcarbamates: New glycosyl donors with tunable reactivity

Hinklin, R. J. and Kiessling, L. L. (2001)
J. Am. Chem. Soc. 123, 3379-80. [PDF]

High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide

Nilsson, B. L., Kiessling, L. L., and Raines, R. T. (2001)
Org. Lett. 3, 9-12. [PDF]

Chemical glyobiology

Bertozzi, C. R. and Kiessling, L. L. (2001)
Science 291, 2357-2364. [PDF]

The Periodic Table

Kiessling, L. L. (2001)
Chem. Eng. News 79, 246.

Synthesis of cyclic sulfates by halocyclization

Steinmann, J. G., Phillips, J. H., Sanders, W. J., and Kiessling, L. L. (2001)
Org. Lett. 3, 3557-3559. [PDF]

Visualization of single multivalent receptor-liggand complexes by transmission electron microscopy

Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000)
Angew. Chem. Int. Ed. Eng. 39, 4567-4570. [PDF]

Evolutionary conservation of methyl-accepting chemotaxis protein location in bacteria and archea

Gestwicki, J. E., Lamanna, A. C., Harshey, R. M., McCarter, L. L., Kiessling, L. L., and Adler, J. (2000)
J. Bacteriol. 182, 6499-6502. [PDF]

Tuning chemotactic responses with synthetic multivalent ligands

Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000)
Chem. Biol. 7, 583-591. [PDF]

Staudinger ligation: A peptide from a thioester and azide

Nilsson, B. L., Kiessling, L. L, and Raines, R. T. (2000).
Org. Lett. 2, 1939-1941. [PDF]

Motility and chemotaxis of filamentous cells of Escherichia coli

Maki, N., Gestwicki, J. E., Lake, E. M., Kiessling, L. L. and Adler, J. (2000)
J. Bacteriol. 182, 4337-4342. [PDF]

Synergistic formation of soluble lectin clusters by a templated multivalent saccharide ligand

Burke, S. D., Zhao, Q., Schuster, M. C., and Kiessling, L. L. (2000)
J. Am. Chem. Soc. 122, 4518-4519. [PDF]

Synthesis of end-labeled multivalent ligands for exploring cell surface receptor ligand interactions

Gordon, E. J., Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000)
Chem. Biol. 7, 9-16. [PDF]

Synthetic multivalent ligands in the exploration of cell surface interactions

Kiessling, L. L., Gestwicki, J. E., and Strong, L. E. (2000)
Curr. Opin. Chem. Biol. 4, 696-703. [PDF]

Principles for multivalent ligand design.

Kiessling, L. L, Strong, L. E., and Gestwicki, J. E. (2000)
Annu. Reports Med. Chem 35, 321-330. [PDF]

Scope of multivalent ligand function: Lactose-bearing neoglycopolymers by ring-opening metathesis polymerization

Pohl, N. L. and Kiessling, L. L. (1999)
Synthesis SI, 1515-1519. [PDF]

A general synthetic route to defined, biologically active multivalent arrays

Strong, L. E. and Kiessling, L. L. (1999)
J. Am. Chem. Soc. 121, 6193-6196. [PDF]

Recognition sequence design for peptidyl modulators of b-amyloid aggregation and toxicity

Pallitto, M. M., Ghanta, J., Heinzelman, P., Kiessling, L. L., and Murphy, R. M. (1999)
Biochemistry 38, 3570-3578. [PDF]

Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics

Sanders, W. J., Gordon, E. J., Dwir, O., Beck, P. J., Alon, R. T., and Kiessling, L. L. (1999)
J. Biol. Chem. 274, 5271-5278. [PDF]

Modulation of nucleic acids, carbohydrates and proteins to different task

Kiessling, L. L., DeGrado, W. F., and Ecstein, F. (1999)
Curr. Opin. Chem. Biol. 3(6), 641-642. [PDF]

Probing low affinity and multivalent interactions with surface plasmon resonance: Ligands for Concanavalin A

Mann, D. A., Kanai, M., Maly, D. J., and Kiessling, L. L. (1998)
J. Am. Chem. Soc. 120, 10375-10383. [PDF]

Glycoprotein-inspired materials promote the proteolytic release of cell surface L-selectin

Gordon, E. J., Strong, L. E., and Kiessling, L. L. (1998)
Bioorg. Med. Chem. 6, 1293-1299. [PDF]

Synthetic ligands point to cell surface strategies

Gordon, E. J., Sanders, W. J., and Kiessling, L. L. (1998)
Nature 392, 30-31. [PDF]

Transforming the extracellular environment through proteolysis

Kiessling, L. L. and Gordon, E. J. (1998)
Chemistry & Biology 5, R49-62. [PDF]

Synthesis of sulfated trisaccharide ligands for the selectins

Sanders, W. J., Manning, D. D., Koeller, K., and Kiessling, L. L. (1997)
Tetrahedron Symposium in Print: Synthetic Methods 53, 16391-16422. [PDF]

Varying the size of multivalent ligands: The dependence of Concanavalin A inhibition on neoglycopolymer length

Kanai, M., Mortell, K. H., and Kiessling, L. L. (1997)
J. Am. Chem. Soc. 119, 9931-9932. [PDF]

Para-chloro benzyl groups as stabilizers of the glycosidic linkage

Pohl, N. L. and Kiessling, L. L. (1997)
Tetrahedron Lett. 38, 6985-6988. [PDF]

Neoglycopolymer inhibitors of the selectins

Manning, D. D., Strong, L. E., Hu, X., Beck, P. J., and Kiessling, L. L. (1997)
Tetrahedron Symposium in Print: Bioorg. Chem. 53, 11937-11952.

Synthesis of sulfated neogly-copolymers: Selective P-selectin inhibitors

Manning, D. D., Hu, X., Beck, P. J., and Kiessling, L. L. (1997)
J. Am. Chem. Soc. 119, 3161-3162. [PDF]

Solution conformation of Lewis a-derived selectin ligands is unaffected by anionic substituents at the 3′- and 6′-positions

Kurutz, J. K. and Kiessling, L. L. (1997)
Glycobiol. 7, 337-347. [PDF]

Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper (II) macrocycle Cu([9]aneN3)Cl2

Hegg, E., Deal, K., Kiessling, L. L, and Burstyn, J. N. (1997)
Inorg. Chem. 36, 1715-1718. [PDF]

Neoglycopolymers produced by ring-opening metathesis polymerization: Decreasing saccharide density increases activity

Schuster, M. C., Mortell, K. H., Hegeman, A. D., and Kiessling, L. L. (1997)
J. Mol. Cat. A: Chemical 116, 209-216. [PDF]

Preparation of R-(+)-7-oxabicyclo[2.2.1]hept-5-ene-exo-2-carboxylic acid, a precursor to substrates for the ring opening metathesis polymerization

Schueller, C. M., Manning, D. D., and Kiessling, L. L. (1996)
Tetrahedron Lett. 37, 8853-8856. [PDF]

Reactivity of a 2′ thio nucleotide analog

Dantzman, C. L. and Kiessling, L. L. (1996)
J. Am. Chem. Soc. 118, 11715-11719. [PDF]

A strategy for designing inhibitors of ?-amyloid toxicity

Ghanta, J., Shen, C.-L., Kiessling, L. L., and Murphy, R.M. (1996)
J. Biol. Chem. 271, 29525-29528. [PDF]

L-selectin carbohydrate onteractions: Relevant modifications of the Lewis x trisaccharide

Sanders, W. J., Katsumoto, T. R., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996)
Biochemistry 35, 14862-14867. [PDF]

Convergent synthesis of sulfated bivalent glycopeptides as selectin ligands

Brüning, J. and Kiessling, L. L. (1996)
Tetrahedron Lett. 37, 2907-2910. [PDF]

Tin-mediated phosphorylation: Synthesis and selectin binding of a phospho Lewis a analog

Manning, D. D., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996)
Tetrahedron Lett. 37, 1953-1956. [PDF]

Recognition specificity of neoglycopolymers prepared by ring-opening metathesis polymerization

Mortell, K. H., Weatherman, R. V., and Kiessling, L. L. (1996)
J. Am. Chem. Soc. 118,2297-2298. [PDF]

Specificity of C-Glycoside complexation by mannose/glucose specific lectins

Weatherman, R. V., Mortell, K. H., Chervenak, M., Kiessling, L. L., and Toone, E. J. (1996)
Biochemistry 35, 3619-3624. [PDF]

Fluorescence anisotropy assays reveal affinities of C- and O-Glycosides for Concanavalin A

Weatherman, R. V. and Kiessling, L. L. (1996)
J. Org. Chem. 61, 534-538. [PDF]

Strength in numbers: Non-natural polyvalent carbohydrate derivatives

Kiessling, L. L. and Pohl, N. L. (1996)
Chemistry & Biology 3, 71-77. [PDF]

Creating molecules: Evolution of randomness

Kiessling, L. L. (1995)
Graven Images 2, 222-228. [PDF]

Selectin saccharide interactions: Revealing structure function relationships with chemical synthesis

Manning, D. D., Bertozzi, C. R., Pohl, N. L., Rosen, S. D., and Kiessling, L. L. (1995)
J. Org. Chem. 60, 6254-6255. [PDF]

Synthesis of cell agglutination inhibitors by aqueous ring-opening metathesis polymerization

Mortell, K. H., Gingras, M., and Kiessling, L. L. (1994)
J. Am. Chem. Soc. 116, 12053-12054. [PDF]

Stereoselective Lewis acid-catalyzed glycosylation of cyclic sulfites

Sanders, W. and Kiessling, L. L. (1994)
Tetrahedron Lett. 35, 7335-7338. [PDF]

Recognition of all four base pairs of double helical DNA by triple helix formation: Design of non-natural deoxyribonucleosides for pyrimidine-purine base pair binding

Griffin, L. C., Kiessling, L. L, Beal, P. A., Gillespie, P., and Dervan, P. B. (1992)
J. Am. Chem. Soc. 114, 7976-7982. [PDF]

Flanking sequence effects within the pyrimidine triple helix motif characterized by affinity cleaving

Kiessling, L. L., Griffin, L. C., and Dervan, P. B. (1992)
Biochemistry 31, 2829-2834. [PDF]

Model of the interactions of calichemicin g1 with a DNA fragment from pBR322

Hawley, R. C., Kiessling, L. L., Schreiber, S. L. (1989)
Proc. Natl. Acad. Sci. USA 86, 1105-1109. [PDF]

Further investigations of the type II Diels-Alder route to the bicyclic core of esperamicin/calichemicin reveal a regio-chemical misassignment: Meta vs. para selectivity

Schreiber, S. L. and Kiessling, L. L. (1989)
Tetrahedron Lett. 30, 433-436. [PDF]

Synthesis of the bicyclic core of the esperamicin/calichemicin class of antitumor agents

Schreiber, S. L. and Kiessling, L. L. (1988)
J. Am. Chem. Soc. 110, 631-633. [PDF]

Natural product-based leads in cancer chemotherapy

Kiessling, L. L. and Schreiber, S L. (1988)
Chemtracts 1, 4-6. [PDF]

Structure activity relationships of 6-(heterocyclyl)-methylene penam sulfones: A new class of b-lactamase inhibitors

Chen, Y. L., Chang, C. W., Hedberg, K., Guarino, K., Welch, W. M., Kiessling, L., Retsema, J., Haskell, S. L., Anderson, M., Manousos, M., and Barrett, J. F. (1987)
J. Antibiotics 40, 803-822. [PDF]